{"id":3952,"date":"2026-02-13T17:04:17","date_gmt":"2026-02-13T23:04:17","guid":{"rendered":"https:\/\/drakarlacastolo.com\/?p=3952"},"modified":"2026-02-13T17:05:26","modified_gmt":"2026-02-13T23:05:26","slug":"prediabetes-insulin-resistance-how-it-affects-the-heart","status":"publish","type":"post","link":"https:\/\/drakarlacastolo.com\/en\/blog\/cardiometabolic-health\/prediabetes-insulin-resistance-how-it-affects-the-heart\/","title":{"rendered":"Prediabetes and insulin resistance: how it affects the heart"},"content":{"rendered":"<p>\u201cPrediabetes\u201d often sounds like \u201cit's not diabetes yet, so it's okay.\u201d That's the mistake. Prediabetes and insulin resistance are signs that the metabolism is already under stress and, in many people, that comes with high blood pressure, high triglycerides, fatty liver, inflammation and cholesterol changes. The heart doesn't wait until \u201cit's already diabetes\u201d.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The most important<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Insulin resistance<\/strong> means that the body needs more insulin to maintain \u201cnormal\u201d sugar. That usually goes with <strong>increased cardiometabolic risk<\/strong>.<\/li>\n\n\n\n<li><strong>Prediabetes<\/strong> is not just a number: it is a phase where you can <strong>reduce risk<\/strong> with sustainable interventions (and, in some cases, treatment).<\/li>\n\n\n\n<li>The real risk is usually the <strong>set<\/strong>glucose + blood pressure + lipids + abdominal weight + sleep\/stress + history.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What is insulin resistance?<\/h2>\n\n\n\n<p>Insulin is a hormone that helps glucose enter the cells to be used as energy. In the <strong>insulin resistance<\/strong>, The cells respond worse, so the body compensates by producing more insulin.<\/p>\n\n\n\n<p>Over time, this \u201cextra effort\u201d can fail: glucose levels rise, prediabetes appears and, in some cases, type 2 diabetes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is prediabetes (in simple words)?<\/h2>\n\n\n\n<p>This is when glucose is <strong>above ideal<\/strong>, but not yet in the diabetes range. It is a relevant stage because:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>usually progresses if the context (habits + weight + sleep + sedentary lifestyle) is not corrected,<\/li>\n\n\n\n<li>and may coexist with other factors that increase cardiovascular risk.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Why does it affect the heart?<\/h2>\n\n\n\n<p>There are several mechanisms (and they are almost always combined):<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1) It is associated with metabolic syndrome (the \u201cpackage\u201d of risk).<\/h3>\n\n\n\n<p>Prediabetes\/insulin resistance often goes along with:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>high pressure<\/strong><\/li>\n\n\n\n<li><strong>high triglycerides<\/strong> and\/or <strong>Low HDL<\/strong><\/li>\n\n\n\n<li><strong>abdominal weight gain<\/strong><\/li>\n\n\n\n<li><strong>fatty liver<\/strong><\/li>\n<\/ul>\n\n\n\n<p>That set increases the risk of cardiovascular disease over time.<\/p>\n\n\n\n<p>For context:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/diagnostic-evaluation\/hypertension\/\">Hypertension<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/diagnostic-evaluation\/blood-pressure-goals-home-blood-pressure-measurement\/\">Blood pressure: goals and measurement at home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/\">High triglycerides and fatty liver: cardiovascular impact<\/a> <em>(if you already published it, here is the interlink to the final post)<\/em><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2) Promotes inflammation and vessel dysfunction.<\/h3>\n\n\n\n<p>In insulin resistance there is usually an environment of low-grade inflammation and changes in the function of the endothelium (the \u201cinner layer\u201d of the vessels). This facilitates, with other factors, the progression of atherosclerosis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3) It is mixed with more relevant cholesterol alterations.<\/h3>\n\n\n\n<p>Many people focus only on \u201csugar\u201d, but cardiovascular risk is decided by the <strong>complete profile<\/strong>, especially LDL and overall risk.<\/p>\n\n\n\n<p>It complements with:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/lifestyle-prevention\/cholesterol\/\">Cholesterol<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/diagnostic-evaluation\/ldl-cholesterol-diagnostic-evaluation-objectives\/\">LDL: objectives and evaluation<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How do I know if I have prediabetes or insulin resistance?<\/h2>\n\n\n\n<p>In clinical practice, a combination of laboratory + context is used.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common studies<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fasting glucose<\/strong><\/li>\n\n\n\n<li><strong>HbA1c (glycosylated hemoglobin)<\/strong><\/li>\n\n\n\n<li>In some cases: glucose tolerance curve (depending on the clinical case)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Facts that matter (and many people ignore)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>waist\/abdomen<\/strong>, weight and trend<\/li>\n\n\n\n<li>blood pressure<\/li>\n\n\n\n<li>triglycerides\/HDL\/LDL<\/li>\n\n\n\n<li>sleep, stress, physical activity<\/li>\n\n\n\n<li>family history of diabetes or heart attack<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warning signs: when medical evaluation is advisable<\/h2>\n\n\n\n<p>Agenda valuation yes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>you already have prediabetes <strong>y<\/strong> in addition: high blood pressure, altered cholesterol, high triglycerides or fatty liver<\/li>\n\n\n\n<li>family history of early myocardial infarction, diabetes, CVD<\/li>\n\n\n\n<li>symptoms that are evaluated separately (not \u201cfor prediabetes\u201d): chest pain, shortness of breath, palpitations, or fainting<\/li>\n<\/ul>\n\n\n\n<p>Lean on:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/emergencies\/chest-pain-in-an-emergency\/\">Chest pain: common causes and when is it an emergency?<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/cardiac-conditions\/shortness-of-breath-when-it-is-of-the-heart\/\">Shortness of breath: when it may be heart-related<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/diagnostic-evaluation\/palpitations-common-causes-and-when-to-worry\/\">Palpitations: common causes and when to worry about them<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What usually helps (without promising results)<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Food: the real objective<\/h3>\n\n\n\n<p>It's not \u201cperfect dieting\u201d. It's reducing triggers that push glucose\/insulin and sustaining what you can maintain.<\/p>\n\n\n\n<p>In general, it helps:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>reducing sweetened beverages, desserts and refined flours<\/li>\n\n\n\n<li>prioritizing sufficient protein and fiber (vegetables\/legumes, according to tolerance)<\/li>\n\n\n\n<li>adjusting portions and schedules (according to your routine and real hunger)<\/li>\n\n\n\n<li>alcohol: in many people worsens triglycerides and metabolic control<\/li>\n<\/ul>\n\n\n\n<p>Practical guide: <a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/lifestyle-prevention\/cardioprotective-nutrition\/\">Cardioprotective nutrition<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Physical activity: insulin sensitivity and blood pressure.<\/h3>\n\n\n\n<p>Physical activity improves insulin sensitivity and helps blood pressure, sleep and triglycerides. The key is to do it <strong>securely<\/strong> and progressive.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/lifestyle-prevention\/physical-activity\/\">Physical activity<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/lifestyle-prevention\/safe-physical-activity\/\">Safe physical activity<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Sleep and stress: not \u201cextras\u201d.\u201d<\/h3>\n\n\n\n<p>Poor sleep and chronic stress alone do not \u201ccreate\u201d prediabetes, but worsen appetite, cravings, recovery and adherence.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/blog\/lifestyle-prevention\/stress-sleep-health-heart\/\">Stress, sleep and heart health<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Medications: depend on profile (not fear)<\/h3>\n\n\n\n<p>In some people (due to global risk, evolution or comorbidities) treatment is considered. This is defined with a complete clinical history, laboratories and clear goals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What may be included in a cardiovascular\/cardiometabolic evaluation?<\/h2>\n\n\n\n<p>It is usually reviewed in consultation:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>overall risk (history, blood pressure, lipids, glucose)<\/li>\n\n\n\n<li>habits (activity, sleep, alcohol, diet)<\/li>\n\n\n\n<li>pressure scanning and measurement<\/li>\n\n\n\n<li>monitoring plan with realistic goals<\/li>\n<\/ul>\n\n\n\n<p>If you are looking for a comprehensive overhaul:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/cardiac-checkup\/\">Cardiac check up<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/cardiology-consultation\/\">Cardiology consultation<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/drakarlacastolo.com\/en\/contact\/\">Contact \/ schedule<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">References<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/diabetesjournals.org\/care\/issue\" data-type=\"link\" data-id=\"https:\/\/diabetesjournals.org\/care\/issue\" target=\"_blank\" rel=\"noopener\">American Diabetes Association. <em>Standards of Care in Diabetes<\/em><\/a> <\/li>\n\n\n\n<li><a href=\"https:\/\/www.cdc.gov\/diabetes\/basics\/prediabetes.html\" data-type=\"link\" data-id=\"https:\/\/www.cdc.gov\/diabetes\/basics\/prediabetes.html\" target=\"_blank\" rel=\"noopener\">CDC. <em>Prediabetes: Your Chance to Prevent Type 2 Diabetes<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.heart.org\/en\/health-topics\/diabetes\/why-diabetes-matters\/diabetes-and-heart-disease-stroke\" data-type=\"link\" data-id=\"https:\/\/www.heart.org\/en\/health-topics\/diabetes\/why-diabetes-matters\/diabetes-and-heart-disease-stroke\" target=\"_blank\" rel=\"noopener\">American Heart Association. <em>Diabetes and Heart Disease<\/em><\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u201cPrediabetes\u201d suele sonar a \u201ctodav\u00eda no es diabetes, entonces no pasa nada\u201d. Ese es el error. Prediabetes y resistencia a la insulina son se\u00f1ales de que el metabolismo ya est\u00e1 bajo estr\u00e9s y, en muchas personas, eso viene acompa\u00f1ado de presi\u00f3n alta, triglic\u00e9ridos altos, h\u00edgado graso, inflamaci\u00f3n y cambios en el colesterol. El coraz\u00f3n no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[46,49],"tags":[],"class_list":["post-3952","post","type-post","status-publish","format-standard","hentry","category-salud-cardiometabolica","category-salud"],"acf":[],"_links":{"self":[{"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/posts\/3952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/comments?post=3952"}],"version-history":[{"count":1,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/posts\/3952\/revisions"}],"predecessor-version":[{"id":3953,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/posts\/3952\/revisions\/3953"}],"wp:attachment":[{"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/media?parent=3952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/categories?post=3952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drakarlacastolo.com\/en\/wp-json\/wp\/v2\/tags?post=3952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}